Nuclear Translocation of Apoptosis-Inducing Factor after Focal Cerebral Ischemia
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چکیده
منابع مشابه
Cyclophilin A participates in the nuclear translocation of apoptosis-inducing factor in neurons after cerebral hypoxia-ischemia
Upon cerebral hypoxia-ischemia (HI), apoptosis-inducing factor (AIF) can move from mitochondria to nuclei, participate in chromatinolysis, and contribute to the execution of cell death. Previous work (Cande, C., N. Vahsen, I. Kouranti, E. Schmitt, E. Daugas, C. Spahr, J. Luban, R.T. Kroemer, F. Giordanetto, C. Garrido, et al. 2004. Oncogene. 23:1514-1521) performed in vitro suggests that AIF mu...
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BACKGROUND AND PURPOSE Recently, apoptosis- inducing factor (AIF), a mitochondrial proapoptotic protein, and its nuclear translocation have been reported in caspase-independent neuronal apoptosis. In this study, we investigated the contribution of reactive oxygen species (ROS) to the nuclear translocation of AIF and the subsequent DNA fragmentation after permanent focal cerebral ischemia (pFCI)...
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Antti Nurmi, Perttu J. Lindsberg, Milla Koistinaho, Wen Zhang, Eric Juettler, Marja-Liisa B Contributes to Infarction After Permanent Focal Ischemia κ Nuclear FactorPrint ISSN: 0039-2499. Online ISSN: 1524-4628 Copyright © 2004 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Stroke doi: 10.1161/01.STR...
متن کاملNuclear translocation of endonuclease G and apoptosis-inducing factor during acetaminophen-induced liver cell injury.
Mitochondrial dysfunction and internucleosomal DNA fragmentation are well-recognized features of acetaminophen (AAP)-induced hepatocyte cell death. However, the endonucleases responsible for this effect have not been identified. Apoptosis-inducing factor (AIF) and endonuclease G are nucleases located in the intermembrane space of mitochondria. AIF is thought to trigger chromatin condensation an...
متن کاملResearch Paper: Optimization of Transient Focal Cerebral Ischemia Model by Middle Cerebral Artery Occlusion
Introduction: Cerebral ischemia is one of the most common causes of death in human populations in the industrial communities. The need for animal models is inevitable to study the pathophysiology and treatment of cerebral ischemia in human. The current study aimed at evaluating the strengths and weaknesses of different techniques used to create ischemia in previous studies and optimizing the tr...
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ژورنال
عنوان ژورنال: Journal of Cerebral Blood Flow & Metabolism
سال: 2004
ISSN: 0271-678X,1559-7016
DOI: 10.1097/00004647-200404000-00011